Jokes are commonplace on April Fools’ Day.

And Chelsea Handler, comedian, likes to hear good jokes. However, on this April Fools’ Day, she is addressing a topic that no one can laugh about.

Handler, along with her Chelsea Lately staff, is joining forces with AbolishCancer, a non-profit group dedicated to raising awareness about the deadly disease. She will be asking her fans to donate $1 on April 1 to a cancer charity of their choice as a part of AbolishCancer’s “1-4/1 Cancer’s No Joke” project.

Those who have read (or listened to the audio book version which the author herself has narrated) Chelsea Handler’s “Are You There Vodka? It’s Me, Chelsea” know that Chelsea’s funny, quirky and sometimes neurotic behavior stems from an equally funny and quirky family. And while we all know by now that actress Laura Prepon has already been cast to play her in the buzz worthy NBC pilot based on the bestselling book, Chelsea won’t be taking a backseat in the series, not off-cam at least, since she’s been cast to play her own older sister in the show. And for us big fans of the book, we all know that sister of hers has caused Chelsea a lot of trouble in the past, including her first DUI arrest.

Chelsea Handler, comedian, has announced dates for her 2011 tour, which has been dubbed “Lies that Chelsea Handler Told Me.” Also performing will be comedians who regularly appear on Handler’s show, “Chelsea Lately,” including Heather McDonald, Brad Wollack, and Josh Wolf. 19 performances have been scheduled including the initial stop in Boston on May 10.

Handler is following up her wildly successful 2010 tour, “Chelsea Chelsea Bang Bank’ with the new dates for 2011. The 2010 venture added additional dates and brought in over 250,000 people in 44 venues. The tour saw a profit of in excess of $16 million.

Chelsea Handler, the controversial American comedian, will be bringing her own tounge-in-cheek humor into Australia for one March gig.

Recently Handler made the headlines when she called Angelina Jolie a home wrecker and evil, and for reportedly dating 50 Cent the rapper. Handler will be performing one show at State Theatre in Sydney on March 10 as part of the “Chelsea Chelsea, Bang Bang World Tour.”v

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Chelsea Handler, “Chelsea Lately” host on E! and comedian, is getting her own Grand Central Publishing imprint. Handler’s books have made a regular appearance on the best seller list. For the imprint she has been given a deal for three books.

The next book from Handler, “Lies That Chelsea Handler Told Me,” is being released in May 2011. It will be issued under Borderline Amazing, her new imprint. Chunk, Handler’s dog, may get his say finally as well.

Chelsea Handler will join Joel McHale, fellow late night host on E!, on NBC. Wait a minute will Chelsea be playing the new alcoholic professor of Greendale’s? We can always hope. There is good news, however. NBC is picking up the pilot for “Are You There Vodka? It’s Me, Chelsea.” The show is based on the popular memoirs of Handler’s.

The comedy will be pulling stories from all three of Handler’s books: “Chelsea Chelsea Bang Bang,” “Are You There Vodka? It’s Me, Chelsea,” and “My Horizontal Life: A Collection of One Night Stands.” The show will focus on a 20 something year old woman’s life, closely resembling Handler, but not having the profession of author/comedian. Handler has lived through these hilarious situations already to help make her books best sellers. So instead of working in front of a camera she will be the executive producer and work behind the scenes along with Tom Brunelle, Borderline Amazing partner, and Mike and Werner Clements of Werner Entertainment. Handler said, the show will draw from my books, providing me with creative control of placing a younger actress in situations that was in at the age of 26, as I sit back and laugh while not getting arrested.

A one-line tweet from E! Network’s resident late night funny gal Chelsea Handler sparked a Twitter outrage from Mr. Mariah Carey himself, comedian Nick Cannon.

After the host of the recently concluded MTV VMAs tweeted “I just heard nick cannon is starting a comedy tour. Who’s going to do the comedy?”, Cannon blasted the host a tirade of tweets ranging from demanding respect from a fellow comedian to personal jabs about the comedienne’s previous relationship with a network head to her current fling with rapper 50 Cent.

“Wow @chelseahandler I actually used to have respect for you as a comic. But for one artist to diss another in the same art form. #Tasteless”

First 50 Cent and Chelsea Handler were seen getting cozy together at a New Orleans club. Handler then denied rumors they had hooked up. She tweeted that she and Mr. Cent had met to talk about a possible project. From now on we’d like all our project meetings held in New Orleans jazz joints.

Judging from Handler’s reaction when a show guest Jo Koy thanked Chelsea for her “banging 50 Cent,” we are skeptical about this being a meeting for business. Chelsea insisted, I am not banging him, although she did admit to blushing. She added, when there is something for me to say, I’ll announce it on my show.

After landing a hosting gig at the recently concluded MTV VMAs last month, E! Network’s queen of late night talk Chelsea Handler is on her way to dominate the said time block as she and her comedic cohorts star in the upcoming E! comedy reality series “After Lately”.

In a report released by Variety, the show will follow the format of a reality show as it unravels the various backstage adventures, and misadventures, that go on when the cameras and lights of “Chelsea Lately” turn off and as Handler puts it, it is the perfect “platform for people who have no business being on camera”. With a more flexible format compared to a scripted sit-com, expect a no-holds-barred comedy that Handler and her gang of stand-up comedians is known for, but this time, with more people and things to make fun of and they themselves are not safe from the pranks and the snide comments.